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Predicting North Star Ambulatory Assessment trajectories in Duchenne muscular dystrophy: A mixed-effects modeling approach

A prognostic model for predicting individual 5-year motor function trajectories in Duchenne muscular dystrophy patients using the North Star Ambulatory Assessment.

Minimal detectable change and meaningful change in motor function in Duchenne muscular dystrophy

Establishes minimal detectable change thresholds for the North Star Ambulatory Assessment in Duchenne muscular dystrophy, accounting for variation across the functional spectrum.

Survival among patients receiving eteplirsen for up to 8 years for the treatment of Duchenne muscular dystrophy and contextualization with natural history controls

Long-term survival analysis comparing eteplirsen-treated Duchenne muscular dystrophy patients to matched natural history controls, demonstrating survival benefits with treatment.

Pathway for Development and Validation of Multi-domain Endpoints for Amyloid Light Chain (AL) Amyloidosis

A framework for developing and validating multi-domain composite endpoints for AL amyloidosis clinical trials, developed through a public-private partnership with the FDA.

Patient characteristics associated with all-cause healthcare costs of alopecia areata in the United States

Analysis of healthcare cost drivers in alopecia areata patients, identifying key demographic and clinical factors associated with cost variation.

Long-term treatment effects of inotersen on health-related quality of life in patients with hATTR amyloidosis with polyneuropathy: Analysis of the open-label extension of the NEURO-TTR trial

Long-term analysis of health-related quality of life outcomes in hereditary transthyretin amyloidosis patients treated with inotersen, demonstrating sustained benefits over extended follow-up.

Deterioration of Health-Related Quality of Life After Withdrawal of Risankizumab Treatment in Patients with Moderate-to-Severe Plaque Psoriasis: A Machine Learning Predictive Model

Machine learning predictive model for quality of life deterioration after risankizumab withdrawal in psoriasis, identifying patient factors that inform re-treatment decisions.

The effects of global budget payments on hospital utilization in rural Maryland

This study evaluates Maryland's global budget reform in rural hospitals, finding that the reform decreased outpatient utilization but did not significantly affect inpatient admissions.

Lifetime job demands and later life disability

Using Health and Retirement Study data linked to occupational classifications, this study examines how lifetime job demands relate to disability in later life.

Guideline-concordant initiation of oral anticoagulant therapy for stroke prevention in older veterans with atrial fibrillation eligible for Medicare Part D

Using data from the VHA linked to Medicare claims, this study analyzed the rate to which Veterans at high risk of stroke received recommended anticoagulation therapy, finding suboptimal rates of guideline-concordant prescribing.